The most common histologic pattern in canine IBD features predominant infiltration by which cell types?

The most common histologic pattern in canine IBD features predominant infiltration by which cell types?

• A. Lymphocytes and plasma cells
• B. Neutrophils
• C. Eosinophils
• D. Macrophages

Answer: (A)

In canine inflammatory bowel disease the most common histologic finding is chronic lymphoplasmacytic inflammation. This means the lining of the gut (the mucosa, especially the lamina propria) is infiltrated predominantly by lymphocytes and plasma cells, reflecting a long-standing, immune-mediated process. You may also see some architectural changes like villous blunting or crypt hyperplasia as a result of ongoing inflammation. This pattern contrasts with other inflammatory patterns: neutrophil-predominant infiltrates point toward acute or septic processes; eosinophil-predominant infiltrates occur in eosinophilic gastroenteritis or certain hypersensitivity-related forms; macrophage-dominant infiltrates are typical of granulomatous diseases. So, the most common histology in canine IBD is lymphocytes and plasma cells.

In canine inflammatory bowel disease the most common histologic finding is chronic lymphoplasmacytic inflammation. This means the lining of the gut (the mucosa, especially the lamina propria) is infiltrated predominantly by lymphocytes and plasma cells, reflecting a long-standing, immune-mediated process. You may also see some architectural changes like villous blunting or crypt hyperplasia as a result of ongoing inflammation.

This pattern contrasts with other inflammatory patterns: neutrophil-predominant infiltrates point toward acute or septic processes; eosinophil-predominant infiltrates occur in eosinophilic gastroenteritis or certain hypersensitivity-related forms; macrophage-dominant infiltrates are typical of granulomatous diseases. So, the most common histology in canine IBD is lymphocytes and plasma cells.